Senescent cell death brings hopes to life

MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes

Senescence is a state of growth arrest resulting mainly from telomere attrition and oxidative stress. It ultimately leads to cell death. We have previously shown that, in keratinocytes, senescence is induced by NF-kappaB activation, MnSOD upregulation and H(2)O(2) overproduction. We have also shown that senescent keratinocytes do not die by apoptosis but as a result of high macroautophagic acti...

DAMPs from Cell Death to New Life

Our body handles tissue damage by activating the immune system in response to intracellular molecules released by injured tissues [damage-associated molecular patterns (DAMPs)], in a similar way as it detects molecular motifs conserved in pathogens (pathogen-associated molecular patterns). DAMPs are molecules that have a physiological role inside the cell, but acquire additional functions when ...

Trends in senescent life expectancy.

The distinction between senescent and non-senescent mortality proves to be very valuable for describing and analysing age patterns of death rates. Unfortunately, standard methods for estimating these mortality components are lacking. The first part of this paper discusses alternative methods for estimating background and senescent mortality among adults and proposes a simple approach based on d...

Photo Animation Brings Scientists Back to Life in the Classroom†

Senescent Human Fibroblasts Resist Programmed Cell Death, and Failure to Suppress bctl Is Involved1

Programmed cell death (apoptosis) is an active process by which cells initiate their own self-destruction. Growing evidence shows that this event is controlled by the activation of unique gene expressions; some function as survival genes, such as bell, and others as killer genes, such as cedi or interleukin converting enzyme. Likewise, external factors, such as the presence or absence of stimul...